Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation.

نویسندگان

  • Christopher J Kuckleburg
  • Shaadi F Elswaifi
  • Thomas J Inzana
  • Charles J Czuprynski
چکیده

Histophilus somni-induced platelet aggregation was inhibited by antagonists of the platelet-activating factor (PAF) receptor but not inhibitors of PAF synthesis. In addition, H. somni cells expressing phosphorylcholine (ChoP) induced aggregation, while ChoP(-) H. somni cells did not. This suggests that H. somni ChoP may induce platelet aggregation via interactions with the PAF receptor.

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عنوان ژورنال:
  • Infection and immunity

دوره 75 2  شماره 

صفحات  -

تاریخ انتشار 2007